To TAP or not to TAP: alternative peptides for immunotherapy of cancer
Current Opinion in Immunology(2020)
摘要
•TAP function is often abrogated in malignant and virus-infected cells.•TAP-deficiency allows presentation of an alternative immunopeptidome.•TAP-independent peptides are predominantly derived from signal sequences and C-terminal ‘tails’.•TAP-independent peptides are potential tumor antigens for immunotherapy.
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