Monogenic and Polygenic Contributions to Atrial Fibrillation Risk

Seung Hoan Choi,Sean J. Jurgens,Lu-Chen Weng,James P. Pirruccello,Carolina Roselli,Mark Chaffin, Christina J.-Y. Lee,Amelia W. Hall,Amit V. Khera,Kathryn L. Lunetta,Steven A. Lubitz,Patrick T. Ellinor

Circulation Research（2020）

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摘要

Rationale: Genome-wide association studies have identified over 100 genetic loci for atrial fibrillation (AF); recent work described an association between loss-of-function (LOF) variants in TTN an...

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