Proteomic and Phosphoproteomic Analyses Identify Novel Targets Involved in Beneficial Effect of Rolipram on Liver Fibrosis in Mice

Leila Gobejishvili,Michael Merchant,Walter Rodriguez-Alvarez,Yali Wang,Daniel Wilkey,Philip Bauer,Claudio Maldonado,Shirish Barve,Craig McClain

FASEB JOURNAL（2019）

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摘要

Background Chronic liver injury leads to the development of liver fibrosis for which there is no therapy. We have shown that phosphodiesterase 4 (PDE4) plays a pathogenic role in the development of...

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