A CMOS Read-Out IC for Cyanobacteria Detection with 40 nApp Sensitivity and 45 dB Dynamic Range
IEEE Sensors Journal(2020)
摘要
This paper presents a low-power high-sensitivity CMOS read-out integrated circuit (ROIC) realized in a 0.13
$ {\mu }\text{m}$
CMOS technology for cyanobacteria detection and monitoring with the current sensing capability of nano-ampere levels. The proposed CMOS ROIC consists of a current-conveyor transimpedance amplifier (CC-TIA) and a 9 bit successive approximation register (SAR) analog-to-digital converter (ADC). Electrically measured results of the proposed ROIC demonstrate 98.6 dB
$\Omega $
transimpedance gain, 1.19 pA/
$\surd $
Hz noise current spectral density, and 1.8 mA current consumption from a single 1.2 V supply. The ROIC can precisely recover the digital output codes corresponding to the input current levels of 40 nA
pp
~ 7.2
$\mu$
A
pp
(i.e., 45 dB dynamic range). Optical experiments utilizing a 405 nm wavelength laser source and a low-cost PIN-photodiode confirm the fluorescence intensity with respect to the quantity of cyanobacteria, demonstrating that the normalized voltage (QD
655
/QD
565
) is a linear function of the mcyD gene copy numbers. The CMOS ROIC chip occupies the area of 1.1
$\times$
2.0 mm
2
.
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关键词
CMOS,current-conveyor,cyanobacteria,SAR ADC,transimpedance amplifier
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