Proteomic analysis of pyridoxal oxime derivatives treated Listeria monocytogenes reveals down-regulation of the main virulence factor, Listeriolysin O

Martina Šrajer Gajdošik,Uroš Andjelković,Dajana Gašo-Sokač,Hrvoje Pavlović,Olga Shevchuk,Tamara Martinović,James Clifton,Marija Begić,Djuro Josić

Food Research International（2020）

引用 8|浏览24

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摘要

•Pyridoxal oxime derivatives (POD) caused significant changes in bacterial proteome.•Most changes in expression of key cell antigens were observed.•Treatment with PODs caused significant downregulation of toxin listeriolysin O (LLO).•Listeriolysin O is a potential biomarker candidate for L. monocytogenes contamination.

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关键词

Foodborne pathogens,Listeriolysin O,Mechanism of action,Proteome changes,Growth inhibition,Biomarker candidate,Fast diagnosis of listeriosis

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