Tumor-derived extracellular vesicles and microRNAs: Functional roles, diagnostic, prognostic and therapeutic options

Giada Pontecorvi,Maria Bellenghi,Rossella Puglisi,Alessandra Carè,Gianfranco Mattia

Cytokine & Growth Factor Reviews（2020）

引用 26|浏览18

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摘要

•Tumor cells transfer oncogenic activity by exosome release.•MiRNAs are loaded into exosomes by selective mechanisms.•Exosomal miRNAs communicate with cells of the tumor microenvironment.•This interaction influence tumor progression and metastatization.

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关键词

EXO,ILVs,MVBs,ESCRT,DC,PA,SNARE,RISC,EMT,hnRNP,nSMase2,TP53INP1,NFs,CAFs,B4GALT3,MAPK,TLRs,EOC,TAMs,OC,MDSC,ER,CSC,DENND2D,PDLIM2,NCOR1,DDR,KLFs,CSCC,VASH1,Neurod1

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