Evaluation of oxidative stress and its modulation by L-Arginine and L-Ascorbic acid in repetitive restraint stress model in Wistar rats

•Study demonstrated reversal of oxidative stress markers by L-Arginine and L- Ascorbic acid.•L-Arginine and L- Ascorbic acid can be used therapeutically in disease associated with high oxidative stress.•Can be used in pathophysiological conditions associated with high oxidative stress.