The role of hepatic sinusoidal obstruction in the pathogenesis of the hepatic involvement in HELLP syndrome: Exploring the literature

Victoria von Salmuth, Yosta van der Heiden, Ilse Bekkers,Pieter van Runnard Heimel,Marc A. Spaanderman,Louis L. Peeters,Ger H. Koek

Pregnancy Hypertension(2020)

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摘要
•Insight in the exact mechanism of liver dysfunction in HELLP syndrome remains limited.•The interplay between the so called "placenta-endothelium-liver axis" seems key in the development of HELLP.•Similar characteristics with SOS include a strong inflammatory stimulus targeting the hepatic sinusoids, ischemic damage and pro-coagulant microcirculatory architecture.•Reported clinical, histological and radiological data show resemblance of HELLP syndrome and SOS.
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关键词
HELLP syndrome,Sinusoidal obstruction syndrome (SOS),Placental dysfunction,Liver dysfunction,Endothelial activation,Systemic inflammatory
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