Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome
Prostaglandins & Other Lipid Mediators(2020)
摘要
•Cytochrome P450 (CYP) enzymes are a class of PUFA metabolizing enzymes that can generate a series of bioactive products.•CYP-derived PUFA epoxides are metabolized by the soluble epoxide hydrolase (sEH) to fatty acid diols.•The CYP-sEH pathway regulates metabolic pathways that are altered in metabolic syndrome and diabetes.
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关键词
Cytochrome P450 enzymes,Insulin resistance,Metabolic syndrome,Polyunsaturated fatty acids
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