LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons

Dear Editor, GABAergic intemeurons (GIs) play an essential inhibitory role in regulating neural circuitry and neurological activities.Approximately 54％ GABAergic interneuron population originated from medial ganglionic eminence (MGE) at E13.5 in rodents (Butt et al.,2005),and migrated from MGE to dorsal cortex tangentially starting at E13-14 after the GABAergic neurons become postmitotic.Dysfunction of GABAergic interneurons causes severe neurological diseases,such as autism,schizophrenia and depression.Recent years,many studies have shown transplantation of GIs improved the neuronal function of animal models such as epilepsy,neuropathic pain,and fear erasure (Bráz et al.,2012;Cunningham et al.;Yang et al.,2016).Since migration is the intrinsic nature of GIs,regulation of GIs migration could be essential for cell therapy.However,the mechanism of human GIs migration remains unknown,which brings difficulties to control cell migration after transplantation.