Contraction Force Analysis Using Optical Imaging in Normal and Mybpc3-Mutated iPSC-Derived Cardiomyocytes Grown on Matrices With Tunable Stiffness

Julia Hofmann,Otto Mulleners,Tessa Noordermeer, Juancito van Leeuwen,Oscar Bartulos, Pieter Voskamp,Stefan Braam, Zeno Guttenberg,Jan Danser,Danielle Majoor-Krakauer,Ingrid van der Pluijm,Erik Meijering,Jeroen Essers

Circulation（2018）

引用 23|浏览14

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摘要

Introduction: Mutations in MYBPC3 (Myosin Binding Protein C) underlie 40% of hypertrophic cardiomyopathy cases in The Netherlands. MYBPC3 codes for the thick filament associated protein cardiac myo...

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关键词

Contractility,Hypertrophic cardiomyopathy,Cardiovascular imaging

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