Acoustoelasticity Analysis Of Shear Waves For Nonlinear Biomechanical Characterization Of Oil-Gelatin Phantoms
2019 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)(2019)
摘要
Shear waves speed (SWS) has found use in staging the liver fibrosis; however, it has shown poor specificity in the early detection and staging of nonalcoholic fatty liver disease (NAFLD) and it is found that SWS may act as a confounding factor to that end, especially with fibrosis that typically coexist. Different tissue compositions exhibit varying nonlinear characteristics. The nonlinear relationship of shear modulus as a function of applied stress/strain can be deduced using acousto-elasticity analysis. In this work, we are studying nonlinear characteristics of two sets of oil-gelatin phantoms: one set of phantoms represent steatotic stages while the other set emulates additional biomechanical changes following the onset of fibrotic processes in the liver. We found that the nonlinear mechanical parameter we estimated, known as 'A', decreased from -16.9 kPa to -4.6 kPa with the progression of emulated steatosis, later increasing to -21.0 kPa with the emulation of fibrosis progression. The results from these in-vitro phantom experiments demonstrate the potential of using acousto-elastic analysis and non-linear characteristics of shear-wave travel as a biomarker in reducing the confounding effects of SWS for the early detection and staging of liver steatosis; with a model demonstrated to disentangle fibrotic and steatotic processes.
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关键词
Ultrasound, Shear-wave elastography, Liver, Steatosis, Fibrosis
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