A case of myelodysplastic syndrome with t(10;18)(q26;q21)

An 82-year-old male was admitted. Pancytopenia, a slightly low white blood cell count (3400/mu L), and low levels of red blood cells (2.65 x 10(6)/mu L), hemoglobin (10.4 g/dL), and platelets (118,000/mu L) were observed. Bone marrow aspiration was performed, revealing hypocellular bone marrow and normal blast levels (0.6%) with no dysplasia. G-banding chromosome analysis revealed the karyotype 45,X,-Y[3]/45, idem, t(10;18)(q26;q21)[13]/46,XY[4]. The patient was diagnosed with myelodysplastic syndrome, unclassified (MDS-U). This is the first case report demonstrating a patient with the chromosomal translocation, t(14;18)(q32;q21), which is extremely rare. This chromosomal aberration was critical for the diagnosis of MDS in this patient.