Combining Doxorubicin-Loaded Pegylated Poly(Lactide-Co-Glycolide) Nanoparticles with Checkpoint Inhibition Safely Enhances Therapeutic Efficacy in a Melanoma Model
ACS Biomaterials Science & Engineering(2020)
摘要
Doxorubicin (DOX) has been widely used for the treatment of various cancers, however, the use of soluble DOX is limited by its low therapeutic index and improved formulations are therefore sought. Aside from its tumoricidal properties, DOX has also been shown to cause an immunogenic form of cell death, however, it is becoming abundantly clear that in situ immune stimulation alone is insufficient to cause significant immune based antitumor activity and that immune checkpoint modulation is also required. In this study, DOX-loaded nanoparticles were made by nanoprecipitation of DOX with a PEGylated poly(lactide-co-glycolide) copolymer (DOX-PLGA-PEG NPs) and were then tested in combination with immune checkpoint blockade (anti-programmed death (anti-PD-1)) in a murine melanoma model in order to enhance antitumor effectiveness. Results showed the prepared particles to be approximately 134 nm in diameter (zeta potential -22 mV) with a loading of 1.75 ug DOX/mg NPs. In vitro release studies (of DOX) revealed the...
更多查看译文
关键词
melanoma,doxorubicin,nanoparticles,anti-PD-1
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络