Peptide nucleic acid-based electrochemical biosensor for simultaneous detection of multiple microRNAs from cancer cells with catalytic hairpin assembly amplification

Pan Fu,Shu Xing,Mengjia Xu,Yang Zhao,Chao Zhao

Sensors and Actuators B: Chemical（2020）

引用 65|浏览64

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摘要

•An electrochemical biosensor for simultaneous detection of miRNAs was developed using PNA and CHA.•This assay was highly selective for discriminating miRNAs with similar sequences.•It has a low LOD of 2.49 fM and 11.63 fM for miRNA21 and miRNA155, respectively.•This assay can be used to detect a variety of miRNAs from human cancer cells at the same time.

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关键词

Peptide nucleic acid (PNA),Electrochemical biosensor,Catalytic hairpin assembly (CHA),Multiplexed miRNA detection

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