Enlarged cardiophrenic lymph nodes predict disease involvement of the upper abdomen and the outcome of primary surgical debulking in advanced ovarian cancer.

CPLNs ≥ 5 mm predict upper abdominal tumor involvement. The application of the CD-Score predicted complete macroscopic tumor resection at primary surgery in 100% of the patients. Although, CPLN pathology suggests extra-abdominal disease, we consistently demonstrated that patients nonetheless benefit from complete intra-abdominal tumor resection.