NOD2 regulates microglial inflammation through the TAK1-NF-κB pathway and autophagy activation in murine pneumococcal meningitis.

Guan Wang,Yanan Fu,Kun Ma, Junli Liu,Xinjie Liu

Brain Research Bulletin（2020）

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摘要

•NOD2 promotes microglial inﬂammation through the TAK1-NF-κB pathway.•NOD2 induces autophagy in murine pneumococcal meningitis.•Autophagy reduces inflammatory mediators during S. pneumonia infection.

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关键词

NOD2,shRNA,CNS,RIP2,MAPK,TAK1,LC3,PBS,LDH,HE,Rapa,3-MA

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