Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines

•Medicarpin prevented alteration of TH-17/Treg ratio in DBAJ/1 mice.•Medicarpin prevents cartilage erosion in joints and restores loss of trabeculae.•Medicarpin down-regulated levels of various pro-inflammatory cytokines.•Medicarpin is effective in preventing arthritis in post-menopausal conditions.