Evaluation of Plasmodium vivax HAP2 as a transmission-blocking vaccine candidate.

Yue Qiu,Yan Zhao,Fei Liu,Bo Ye,Zhenjun Zhao,Sataporn Thongpoon,Wanlapa Roobsoong,Jetsumon Sattabongkot,Liwang Cui,Qi Fan,Yaming Cao

Vaccine（2020）

引用 19|浏览22

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摘要

•Plasmodium vivax HAP2 protein was expressed in baculovirus for immunization.•Transmission-reducing activity was evaluated with four P. vivax clinical isolates.•Anti-PvHAP2 antibodies (Ab) significantly reduced infection intensity in mosquitoes.•Anti-PvHAP2 Ab substantially reduced infection prevalence at low parasite exposure.

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Transmission-blocking vaccine,HAP2,Baculovirus expression

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