Influenza virus NS1- C/EBPβ gene regulatory complex inhibits RIG-I transcription

Rashmi Kumari
Rashmi Kumari
Amrita Kumar
Amrita Kumar
Mayim Wiens
Mayim Wiens
Adolfo García-Sastre
Adolfo García-Sastre
Takashi Fujita
Takashi Fujita

Antiviral research, pp. 1047472020.

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Keywords:
C/EBPβInfluenzaNS1RIG-ITranscriptional regulation

Abstract:

Influenza virus non-structural protein 1 (NS1) counteracts host antiviral innate immune responses by inhibiting Retinoic acid inducible gene-I (RIG-I) activation. However, whether NS1 also specifically regulates RIG-I transcription is unknown. Here, we identify a CCAAT/Enhancer Binding Protein beta (C/EBPβ) binding site in the RIG-I promo...More

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