Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer.

C Conefrey,J L Donovan,R C Stein,S Paramasivan,A Marshall,J Bartlett,D Cameron, A Campbell,J Dunn, H Earl,P Hall, V Harmer,L Hughes-Davies,I Macpherson,A Makris,A Morgan,S Pinder,C Poole,D Rea,L Rooshenas

Clinical Oncology（2020）

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摘要

•Oncologists' routine practice complicated recruitment to a breast cancer trial.•Oncologists selectively approached eligible patients, informed by routine practices.•Use of routine language undermined equipoise in discussions with eligible patients.•Negotiating clinical and research roles can be challenging in de-escalation studies.•Recruitment challenges were overcome through ‘real-time’ investigation and feedback.

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关键词

Breast cancer,de-escalation trial,equipoise,qualitative research,randomised controlled trials,recruitment

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