Use Of Infliximab In The Treatment Of Macrophage Activation Syndrome Complicating Kawasaki Disease
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY(2021)
摘要
Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology. KD can be complicated with macrophage activation syndrome. The optimal treatment for this KD complication has not been established, and a variety of treatments have been used. Infliximab, a chimeric monoclonal antibody that binds tumor necrosis factor, has proved to be efficacious in IV gammaglobulin resistant KD. We present 2 cases of KD complicated with macrophage activation syndrome, including 1 patient with DiGeorge syndrome successfully treated with a combined treatment of IV gammaglobulin, corticosteroids, cyclosporine, and infliximab.
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关键词
Kawasaki disease, macrophage activation syndrome, infliximab
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