Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458

Yu-Fan Chen
Yu-Fan Chen
Yi-Shuan J Li
Yi-Shuan J Li
Men Yee Chiew
Men Yee Chiew
Jennifer Hui-Chun Ho
Jennifer Hui-Chun Ho

Science advances, 2020.

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Abstract:

During endoderm formation, cell identity and tissue morphogenesis are tightly controlled by cell-intrinsic and cell-extrinsic factors such as biochemical and physical inputs. While the effects of biochemical factors are well studied, the physical cues that regulate cell division and differentiation are poorly understood. RNA sequencing an...More

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