Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes.

Franziska Büscheck,Christoph Fraune,Ronald Simon,Martina Kluth,Claudia Hube-Magg,Christina Möller-Koop, Imren Sarper,Kathrin Ketterer,Tjark Henke,Christian Eichelberg,Roland Dahlem,Waldemar Wilczak,Guido Sauter,Margit Fisch,Till Eichenauer,Michael Rink

Oncotarget（2020）

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摘要

The presence of a VHL mutation in virtually all renal tumor subtypes suggests that VHL analysis cannot be used to distinguish between renal tumor subtypes. Consequently, anti-VHL treatment strategies should not be limited to patients with clear cell cancer.

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关键词

3p copy number,VHL mutation,fluorescence in-situ hybridization,renal cell tumors,von Hippel-Lindau gene

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