Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.

Eric M Gordon,Matthew A J Duncton, Brian J Wang, Longwu Qi,Dazhong Fan,Xianfeng Li,Zhi-Jie Ni, Pingyu Ding, Ruslan Grygorash, Eddy Low, Guijun Yu, Jiawei Sun

ACS medicinal chemistry letters（2020）

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摘要

Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam.

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Prodrug,sulfate,aztreonam,antibiotic

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