Synthesis and in vitro activity of asymmetric indole-based bisamidine compounds against Gram-positive and Gram-negative pathogens.

Xiaofang Chen,Yonghua Liu,Chong Wang,Xinxin Hu,Yanbin Wu, Yongzhong Zhang,Cong Bian,Xuefu You,Laixing Hu

Bioorganic & Medicinal Chemistry Letters（2020）

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摘要

•The symmetry of the lead compound’s structure had a great influence on its activity.•Most compounds demonstrated powerful antibacterial activity against the strains.•Some compounds had better activity against several Gram(−ve) strains than the lead.•Compound 8l displayed the best activity, with 4-fold more potency than the lead.

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关键词

Antibacterial activity,Gram-negative pathogens,Bisamidine,Synthesis

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