The Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU) trial: Detailed statistical analysis plan.

Olav Lilleholt Schjørring,Thomas Lass Klitgaard,Anders Perner,Jørn Wetterslev,Theis Lange,Frederik Keus,Jon Henrik Laake,Matthew Morgan,Minna Bäcklund,Martin Siegemund,Katrin Maria Thormar,Bodil Steen Rasmussen

Acta anaesthesiologica Scandinavica（2020）

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摘要

The HOT-ICU trial and the pre-planned statistical analyses are designed to minimise bias and produce high quality data on the effects of a lower versus a higher oxygenation target throughout ICU admission in acutely admitted adult patients with hypoxaemic respiratory failure.

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关键词

critical illness,intensive care units,oxygen inhalation therapy,pragmatic clinical trial,randomised controlled trial,respiratory insufficiency,statistics

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