Pharmacokinetics and tissue distribution study of liposomal albendazole in naturally Echinococcus granulosus infected sheep by a validated UPLC-Q-TOF-MS method.

•Albendazole and its metabolites were monitored using an UPLC-Q-TOF-MS method.•Method complied related validation guidelines of US-FDA and CFDA.•PK and tissue distribution study of liposomal albendazole were performed.•Emulsion albendazole was used as reference preparation.•The experimental animals were naturally echinococcus granulosus infected sheep.