Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress.

Cui-Cui Zhao,Juan Xu,Qiu-Meng Xie,Xiao-Yun Fan,Guang-He Fei,Hui-Mei Wu

International Immunopharmacology（2020）

引用 19|浏览4

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摘要

•ApoE servers as an endogenous negative regulator of OVA-induced airway inflammation.•OVA-induced activation of NLRP3 inflammasome was augmented in ApoE−/− mice.•OVA-induced oxidative stress was exacerbated in ApoE−/− mice.•OVA-induced mitochondrial fusion/fission was aggravated in ApoE−/− mice.

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关键词

Allergic airway inflammation,ApoE,NLRP3 inflammasome,Oxidative stress,Mitochondrial fusion/fission

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