Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation.

Soleil García-Brito,Laura Aldavert-Vera,Gemma Huguet,Elisabet Kádár,Pilar Segura-Torres

Neurobiology of Learning and Memory（2020）

引用 7|浏览8

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摘要

•SB-334867 impairs both spatial memory and visual discrimination in the MWM.•ICSS compensates for the detrimental effects of SB-334867 on both memory paradigms.•OX1R blockade partially negates the facilitating effect of ICSS on spatial memory.•OX1R blockade severely hinders ICSS facilitation of the discrimination task.•The orexinergic system’s involvement in ICSS facilitative effect is task-dependent.

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关键词

Intracranial self-stimulation,Spatial memory,Simultaneous visual discrimination memory,Morris Water Maze,OX1R,SB-334867

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