Transmission Of Ns5a-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected With Hepatitis C Virus Genotype 1a

Stephanie Popping, Rosanne Verwijs,Lize Cuypers,Mark Claassen,Guido van den Berk,Anja De Weggheleire,Joop Arends,Anne Boerekamps,Richard Molenkamp,Marion Koopmans,Annelies Verbon,Charles Boucher,Bart Rijnders,David van de Vijver

CLINICAL INFECTIOUS DISEASES（2020）

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摘要

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

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关键词

hepatitis C virus, resistant associated substitutions, phylogenetic analysis, the WHO 2030 elimination goals, HIV co-infected MSM

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