Durable therapeutic gain despite competing mortality in long-term follow-up of a randomized hyperfractionated radiotherapy trial for locally advanced head and neck cancer.
Clinical and Translational Radiation Oncology(2020)
摘要
•Hyperfractionated RT with augmented dose provides durable enhanced disease control.•Late toxicity is unchanged with higher optimal doses using smaller fraction sizes.•Hyperfractionation improves overall survival but mortality profile evolves over time.•Altered fractionation should avoid unnecessary RT protraction to maximize control.•Excessive acceleration should be avoided to minimize severe normal tissue sequelae.
更多查看译文
关键词
Head and neck cancer,Radiotherapy,Hyperfractionation,Long-term follow-up,Competing mortality
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络