Bacteriophage Qβ virus-like particles displaying Chikungunya virus B-cell epitopes elicit high-titer E2 protein antibodies but fail to neutralize a Thailand strain of Chikungunya virus.

Rupsa Basu,Lukai Zhai, Brenna Rosso,Ebenezer Tumban

Vaccine（2020）

引用 6|浏览3

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摘要

•Immunization with 5 µg of CHIKV E2 peptide not displayed on VLPs is not immunogenic.•CHIKV E2 peptides can be displayed on bacteriophage VLPs.•Immunization with 5 µg of Qβ VLPs displaying E2 peptides is immunogenic.•Sera from bacteriophage VLPs-E2-immunized mice did not neutralize CHIKV.

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关键词

Chikungunya virus,Qβ virus-like particles (VLPs),B-cell epitopes,Vaccine,Neutralization,FRNT

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