Endoscopic duodenal mucosal resurfacing improves glycaemic and hepatic indices in type 2 diabetes: 6-month multicentre results.

JHEP Reports(2019)

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摘要
Insulin resistance is a core pathophysiological defect underscoring type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Both conditions improve with duodenal exclusion surgery. Duodenal mucosal resurfacing (DMR) is an endoscopic intervention developed to treat metabolic disease which has been shown to improve glycaemia in patients with poorly controlled T2DM. Herein, we aimed to further analyse the effects of DMR on hepatic and metabolic parameters in this patient cohort.
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关键词
Duodenal Mucosal Resurfacing,therapeutic endoscopy,Type 2 Diabetes Mellitus,T2DM,Metabolic Syndrome,Blood Glucose,Glycated Haemoglobin A1c,NAFLD,Non-Alcoholic Fatty Liver Disease,Aminotransferase levels,Insulin Resistance,Metabolomics
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