Targeting SGK1 enhances the efficacy of radiotherapy in locally advanced rectal cancer.

Chunlian Zhou,Weiwei Xiao,Ting Jiang,Zhiwei Guo,Min Li,Hui Chang,Yingsong Wu,Minshan Chen,Mude Shi,Weiwen Xu,Yuanhong Gao

Biomedicine & Pharmacotherapy（2020）

引用 8|浏览8

暂无评分

摘要

•Overexpression of SGK1 in LARC correlated with radioresistance.•Pharmacologic inhibition of SGK1 reduced the radioresistance of LARC in vitro and in vivo.•SGK1 is a key player in LARC radioresistance and drives radioresistance in an ATF3 dependent manner.

查看译文

关键词

SGK1,Radiotherapy,Locally advanced rectal cancer,ATF3,Neoadjuvant chemoradiotherapy

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要