Predictors of asynchronies during assisted ventilation and its impact on clinical outcomes: The EPISYNC cohort study.

•Intrinsic PEEP at intubation was a predictor of high incidence of asynchrony (AI≥10%), but static compliance and airway resistance were not•Severity of illness was also associated with high incidence of asynchrony•Double triggering was the most frequent type of asynchrony in subjects under controlled ventilation.•During assisted ventilation, ineffective efforts were more common.•AI≥10% during assisted ventilation was associated with extubation failure, but not with mortality