Di-n-butyl phthalate (DBP) reduces epithelial-mesenchymal transition via IP3R in hypospadias during maternal exposure.

Yi-Ping Zhu,Wei Zhao,Wen-Lan Sun,Sheng Zhao,Min Chen,Lei Pan,Zheng Zhou,Shu-Jie Xia,Jun-Tao Jiang

Ecotoxicology and Environmental Safety（2020）

引用 6|浏览23

暂无评分

摘要

•IP3R expression and EMT abnormalities may be related to the incidence of hypospadias.•DBP can influence the development of GT through its oxidative stress effect.•Calcium concentration and EMT inhibition block the fusion process of urethral groove.•A new molecular mechanism of hypospadias occurrence.

查看译文

关键词

di-n-butyl phthalate,Oxidative stress,Inositol 1,4,5-trisphosphate receptors,Epithelial-mesenchymal transition,Hypospadias

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要