Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Maria Peleli,Sofia-Iris Bibli,Zhen Li,Athanasia Chatzianastasiou,Aimilia Varela,Antonia Katsouda,Sven Zukunft,Mariarosaria Bucci,Valentina Vellecco,Constantinos H Davos,Noriyuki Nagahara,Giuseppe Cirino,Ingrid Fleming,David J Lefer,Andreas Papapetropoulos

Biochemical Pharmacology（2020）

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摘要

Overall, genetic ablation of 3-MST impacts on the mouse cardiovascular system in an age-dependent manner. Loss of 3-MST exerts a cardioprotective role in young adult mice, while with ageing it predisposes them to hypertension and cardiac hypertrophy.

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3-MP,3-MST,3-MST−/−,Ach,BSA,CBS,CD 31,CDH2,cGMP,CO,CSE,DAF-FM DA,DEA-NONOate,DHE,DMPD,DMSO,DTT,EDD,EF (%),EGTA,eNOS,ESD,FS (%),GAPDH,GC,GSH,h/r,H2S,H2Sn,H2O2,HEPES,HPLC,HR,IVSd and IVSs,LAD,LC-MS/MS,LV,MIM,MRM,NADPH,Na2S,NO,NP-40,O2−,PBS,PE,PEEP,PKG-I,PLP,PWd,PWs,RIPA,ROS,SDS,sGC,SSP4,TCA,TRIS,TTC,WT

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