TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer

Kelong Fan
Kelong Fan
Lin Wang
Lin Wang
Xiangji Ying
Xiangji Ying
Ting Guo
Ting Guo
Meng Zhou
Meng Zhou
Huirong Ding
Huirong Ding
Ziyu Li
Ziyu Li

Cell death & disease, pp. 922020.

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Abstract:

H-ferritin (HFn) nanocarrier is emerging as a promising theranostic platform for tumor diagnosis and therapy, which can specifically target tumor cells via binding transferrin receptor 1 (TfR1). This led us to investigate the therapeutic function of TfR1 in GC. The clinical significance of TfR1 was assessed in 178 GC tissues by using a ma...More

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