Investigation of protective effects of apilarnil against lipopolysaccharide induced liver injury in rats via TLR 4/ HMGB-1/ NF-κB pathway.

•Apilarnil treatment reduced the histopathological changes caused by LPS.•Expressions of TLR4 signalling pathway increased by LPS administration were regulated by apilarnil treatment.•Apilarnil regulated increased apoptosis by LPS administration.•Apilarnil showed protective effect against DNA damage caused by LPS application.•Apilarnil showed protective effect against oxidative stress caused by LPS.