Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance

Chin-Sung Kuo
Chin-Sung Kuo
Liang-Yu Lin
Liang-Yu Lin
Geert W Schmid-Schönbein
Geert W Schmid-Schönbein

Scientific reports, pp. 1725-11, 2020.

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Abstract:

Recent evidence suggests that enhanced protease-mediated inflammation may promote insulin resistance and result in diabetes. This study tested the hypothesis that serine protease plays a pivotal role in type 2 diabetes, and inhibition of serine protease activity prevents hyperglycemia in diabetic animals by modulating insulin signaling pa...More

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