Molecular hybrid design, synthesis, in vitro and in vivo anticancer evaluation, and mechanism of action of N-acylhydrazone linked, heterobivalent β-carbolines.

A novel series of 20 new heterobivalent β-carbolines have designed and synthesized, and their cytotoxic activities in vitro and antitumor efficacies in vivo were evaluated. Moreover, compound 10e has a certain impairment in the motility of LLC cells, which suggests the anti-metastatic potential. And 10e on the angiogenesis process was investigated using a chicken chorioallantoic membrane (CAM) in vivo model.