ApoE mimetic improves pathology and memory in a model of Alzheimer's disease.

Kamesh Krishnamurthy,Viviana Cantillana,Haichen Wang,Patrick M Sullivan,Bradley J Kolls,Xintong Ge,Yufeng Lin,Brian Mace,Daniel T Laskowitz

Brain Research（2020）

引用 20|浏览18

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摘要

•apoE mimetic CN-105 in young APP/PS1/APOETR mice reduces soluble amyloid and amyloid area.•apoE mimetic CN-105 in young APP/PS1/APOETR mice reduces spatial learning deficits.•Delaying treatment onset to 25–28 weeks did not produce as robust an effect.

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关键词

Alzheimer’s disease,CN-105,Apolipoprotein E,Neurodegeneration

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