Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans.

So-Young Kwak,InHyeok Chung, Joon Kang,Nikolaos Perakakis,Eun Hye Yoo,Juhee Lee, Hun Taek Jung,Bo-Ram Mun,Won-Seok Choi,Oh Yoen Kim,Seolsong Kim,Eun-Kyoung Kim,Hannah Oh,Christos S Mantzoros,Ji Hyung Chung,Hyeon Soo Kim,Min-Jeong Shin

Metabolism（2020）

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摘要

•IF1 prevents obesity by regulating food intake and sympathetic nerve activation.•The effect of IF1 on food intake is sex-specific in HFD induced obese mice.•Genetic effect of IF1 on obesity prevalence is sex-specific at the population level.

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E2,AMPK,ANOVA,IF1,BMI,BAT,ELISA,exATP,FoxO1,AUC glucose,GTT,GST,H&E,HbA1c,HFD,IRB,KoGES,mTORC,NE,ND,OVX,PBS,RT-PCR,SNP,SEM

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