Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model.

Cyp1 inhibitionprevents doxorubicin-induced cardiomyopathy in a zebrafish heart-failure model. Doxorubicin, a potent chemotherapy drug, has a side effect of inducing heart failure. By using a zebrafish doxorubicin-induced cardiomyopathy model for in vivo small-molecule screening, the cytochrome P450 family (CYP1) was identified as a candidate therapeutic target for clinical cardioprotection. More information can be found in thefull paper by R. T. Peterson et al.