In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma.

Bas D Koster,Tamarah D de Jong,Mari F C M van den Hout,Berbel J R Sluijter,Ronald J C L M Vuylsteke,Barbara G Molenkamp,Saskia Vosslamber,M Petrousjka van den Tol,Alfons J M van den Eertwegh,Tanja D de Gruijl

ONCOIMMUNOLOGY（2020）

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摘要

Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or with GM-CSF. Here we discuss the added value of GM-CSF and show sex-related differences.

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关键词

GM-CSF,CpG,melanoma,dendritic cells,sentinel lymph node

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