Topical transient receptor potential ankyrin 1 antagonist treatment attenuates nociception and inflammation in an ultraviolet B radiation-induced burn model in mice

Maria Fernanda Pessano Fialho,Evelyne da Silva Brum,Natháli Schopf Pegoraro,Ana Claudia Gontijo Couto,Gabriela Trevisan,Letícia Cruz,Sara Marchesan Oliveira

Journal of Dermatological Science（2020）

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摘要

•Peripheral participation of TRPA1 channel in UVB radiation-induced sunburn.•HC030031, a TRPA1 antagonist, reduces UVB radiation-induced nociception.•HC030031 reduces inflammatory parameters in a UVB radiation-induced sunburn model.

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关键词

ANOVA,DMSO,Imax,HRPO,H2O2,KRB,MPO,PWT,ROS,Sf,SEM,SP,TRPA1,UV,UVB

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