Post-treatment with oxcarbazepine confers potent neuroprotection against transient global cerebral ischemic injury by activating Nrf2 defense pathway.

Cheol Woo Park,Ji Hyeon Ahn,Tae-Kyeong Lee,Young Eun Park,Bora Kim,Jae-Chul Lee,Dae Won Kim,Myoung Cheol Shin,Yoonsoo Park,Jun Hwi Cho,Sungwoo Ryoo,Young-Myeong Kim,Moo-Ho Won,Joon Ha Park

Biomedicine & Pharmacotherapy（2020）

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摘要

•OXC post-treatment in transient ischemia protects neurons in hippocampal CA1.•OXC attenuates ischemia-induced oxidative stress in ischemic CA1.•OXC suppresses ischemia-induced neuroinflammation in ischemic CA1.•OXC increases expressions of Nrf2 and its downstream protein HO-1 in ischemic CA1.•A Nrf2 inhibitor abolishes protective effects of OXC against ischemic injury.

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关键词

4-HNE,8-OHG,BR,CA1,CAT,CNS,CV,DHE,F-J B,GPX,HO-1,Iba-1,IL,Nrf2,OXC,PAT,ROS,SMA,SOD,tGCI,TNF,VGSC

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