Hippocampal overexpression of SGK1 ameliorates spatial memory, rescues Aβ pathology and actin cytoskeleton polymerization in middle-aged APP/PS1 mice.

Biyao Lian,Mengying Liu,Zhen Lan,Tao Sun,Zhaoyou Meng,Qing Chang,Zhi Liu,Jiqiang Zhang,Chengjun Zhao

Behavioural Brain Research（2020）

引用 6|浏览9

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摘要

•Decreased SGK1 was detected in the hippocampus of middle-aged APP/PS1 mice.•SGK1 overexpression ameliorated spatial memory impairment of APP/PS1 mice.•SGK1 overexpression altered hippocampal Aβ production, degradation and plaques.•SGK1 overexpression increased CA1 spine density of APP/PS1 mice.•Upregulation of hippocampal SGK1 may be a novel approach against AD.

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关键词

SGK1,APP/PS1 mice,Hippocampus,Spatial memory,Dendritic spine,Rictor

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