Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates.

Irina Peretokina,Ludmila Yu Krylova,Olga V Antonova, Margarita S Kholina,Elena V Kulagina,Elena Yu Nosova,Svetlana G Safonova,Sergey E Borisov,Danila V Zimenkov

Journal of Infection（2020）

引用 30|浏览18

暂无评分

摘要

•Elevated bedaquiline MIC is found in clinical M. tuberculosis isolates.•MIC change is driven by mutations in mmpR (rv0678) and atpE genes.•AtpE substitutions G25S, D28G, D28N, E61D, A63P, and A63V were observed in vivo.•Substitutions in codon 63 of AtpE were likely associated with a higher bedaquiline MIC.

查看译文

关键词

Tuberculosis,Bedaquiline,Drug resistance,AtpE,Mmpr(Rv0678)

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要